Mitochondria are central for various cellular processes that include ATP production,
intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …

Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means.
Nanomolar concentrations of NO immediately, specifically and reversibly inhibit cytochrome …

NO or its derivatives (reactive nitrogen species: RNS) inhibit mitochondrial respiration in two
different ways:(i) an acute, potent, and reversible inhibition of cytochrome oxidase by NO in …

The mitochondrion is a key organelle in the control of cell death. Nitric oxide (NO) inhibits
complex IV in the respiratory chain and is reported to possess both proapoptotic and …

Hemoglobin and myoglobin are among the most extensively studied proteins, and nitrite is
one of the most studied small molecules. Recently, multiple physiologic studies have …

Mitochondrial nitric oxide synthase (mtNOS), its cellular NOS isoform, and the effects of
mitochondrially produced NO on bioenergetics have been controversial since mtNOS was …

NO or its derivatives (reactive nitrogen species: RNS) have three types of actions on
mitochondria: 1) reversible inhibition of mitochondrial respiration at cytochrome oxidase by …

In this report, we show that nitric oxide affects mitochondrial functionality in plant cells and
reduces total cell respiration due to strong inhibition of the cytochrome pathway. The …

BACKGROUND: The reactions between Complex IV (cytochrome c oxidase, CcOX) and
nitric oxide (NO) were described in the early 60's. The perception, however, that NO could …

Tumor micromilieu often shows pronounced acidosis forcing cells to adapt their phenotype
towards enhanced tumorigenesis induced by altered cellular signalling and transcriptional …