OBJECTIVE: This paper reviews the function of the mitochondria and the mechanisms by
which nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) cause …

Clinical, pharmacological, cell, and molecular biological evidence links altered
mitochondrial (mt) DNA replication to the toxicity of nucleoside reverse transcriptase …

Several drugs are currently used that can significantly prolong the course of the infection
with the human immunodeficiency virus (HIV), the cause of the acquired immunodeficiency …

This atlas illustrates pathological changes of peripheral nerves covering experimental and
human, light and electron microscopic, immunohistochemical, morphometric and …

The subject of this review is the interaction between AZT (zidovudine) and mitochondria as
described in papers dealing with AZT therapy both in AIDS patients and in model systems …

New, more effective antiretroviral therapeutic agents [1] and promise from HIV vaccine
studies [2] have not prevented the AIDS epidemic's global spread. Nucleoside reverse …

The possibility of tissue‐specific effects regarding mitochondrial sensitivity to AZT was
evaluated in this study. When mitochondria isolated from liver, kidney, skeletal and cardiac …

Rationale: AZT is commonly administered to seropositive women and their neonates to
prevent mother-to-child transmission of HIV. Recently, animal studies performed in monkeys …

Long-term use of zidovudine (AZT) may cause mitochondrial abnormalities in various
tissues, including a toxic myopathy in AIDS patients associated with mitochondrial DNA …

The present study provides a characterization of the behavioral changes induced in
preweaning mice by prenatal exposure to lamivudine (3TC), an antiviral drug recently …