Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
Arachidonic acid metabolites in cardiovascular and metabolic diseases
T Sonnweber, A Pizzini, M Nairz, G Weiss… - International journal of …, 2018 - mdpi.com
Lipid and immune pathways are crucial in the pathophysiology of metabolic and
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …
cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to …
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
NK Singh, GN Rao - Progress in lipid research, 2019 - Elsevier
lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids,
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
particularly omega-6 and-3 fatty acids, to generate a number of bioactive lipid metabolites. A …
Mammalian lipoxygenases and their biological relevance
H Kuhn, S Banthiya, K Van Leyen - … Acta (BBA)-Molecular and Cell Biology …, 2015 - Elsevier
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …
have been implicated not only in cell proliferation and differentiation but also in the …
Pathological aspects of lipid peroxidation
A Negre-Salvayre, N Auge, V Ayala, H Basaga… - Free radical …, 2010 - Taylor & Francis
Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …
and cellular dysfunction that plays a major role in ageing and most age-related and …
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
Type 1 diabetes is preceded by islet β-cell dysfunction, but the mechanisms leading to β-cell
dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior …
dysfunction have not been rigorously studied. Because immune cell infiltration occurs prior …
Functional and pathological roles of the 12-and 15-lipoxygenases
AD Dobrian, DC Lieb, BK Cole… - Progress in lipid …, 2011 - Elsevier
The 12/15-lipoxygenase enzymes react with fatty acids producing active lipid metabolites
that are involved in a number of significant disease states. The latter include type 1 and type …
that are involved in a number of significant disease states. The latter include type 1 and type …
Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)
I Ivanov, H Kuhn, D Heydeck - Gene, 2015 - Elsevier
Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes, which have been
implicated in a number of physiological processes and in the pathogenesis of inflammatory …
implicated in a number of physiological processes and in the pathogenesis of inflammatory …
Regulation of tissue inflammation by 12-lipoxygenases
A Kulkarni, JL Nadler, RG Mirmira, I Casimiro - Biomolecules, 2021 - mdpi.com
Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …
Systematic review: association of polycystic ovary syndrome with metabolic syndrome and non‐alcoholic fatty liver disease
A Baranova, TP Tran, A Birerdinc… - Alimentary …, 2011 - Wiley Online Library
Aliment Pharmacol Ther 2011; 33: 801–814 Summary Background Polycystic ovary
syndrome (PCOS) is a common disorder for women of child‐bearing age and is associated …
syndrome (PCOS) is a common disorder for women of child‐bearing age and is associated …