The neutrophil is an essential component of the innate immune system, and its function is
vital to human life. Its production increases in response to virtually all forms of inflammation …

SLE is an autoimmune inflammatory disease in which various pro‐and anti‐inflammatory
cytokines, including TGF‐β, IL‐10, BAFF, IL‐6, IFN‐α, IFN‐γ, IL‐17, and IL‐23, play crucial …

Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities that
plays an important role in immune regulation and inflammation. Among other actions, it …

Objective To investigate the safety of therapeutic tumor necrosis factor α (TNFα) blockade in
patients with systemic lupus erythematosus (SLE), in whom this proinflammatory cytokine is …

Reactive oxygen species (ROS) play a key role in the pathophysiological processes of a
wide range of renal diseases. Thus, antioxidants are expected to decrease the vulnerability …

Murine models of systemic lupus erythematosus (SLE) have shown apparently contradictory
evidence in that either (a) tumor necrosis factor (TNF) expression was low and TNF …

Objective. To investigate the pathophysiological effect of interleukin 6 (IL-6) on lupus
nephritis in MRL-Faslpr mice. Methods. We generated IL-6-deficient MRL-Faslpr mice using …

Tumor necrosis factor alpha (TNFα), a pleiotropic cytokine, plays important inflammatory
roles in renal diseases such as lupus nephritis, anti-neutrophil cytoplasmic antibody (ANCA) …

Over the last decade, oxidative stress has been implicated in the pathogenesis of a wide
variety of seemingly unrelated renal diseases. Epidemiological studies have documented an …

Antibody blockade of TNF-α reduces inflammation and scarring in experimental crescentic
glomerulonephritis. Background Tumor necrosis factor-α (TNF-α) is a proinflammatory …