Recent developments in asymmetric multicomponent reactions

C de Graaff, E Ruijter, RVA Orru - Chemical Society Reviews, 2012 - pubs.rsc.org
Multicomponent reactions (MCRs) receive increasing attention because they address both
diversity and complexity in organic synthesis. Thus, in principle diverse sets of relatively …

Impact of natural products on developing new anti-cancer agents

GM Cragg, PG Grothaus, DJ Newman - Chemical reviews, 2009 - ACS Publications
Throughout the ages, Nature has catered to the basic needs of humans, not the least of
which is the provision of medicines for the treatment of a wide spectrum of diseases. Plants …

[HTML][HTML] Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

WRJD Galloway, A Isidro-Llobet, DR Spring - Nature communications, 2010 - nature.com
Biologically active molecules can be identified through the screening of small-molecule
libraries. Deficiencies in current compound collections are evidenced by the continuing …

Multicomponent reactions for the synthesis of pyrroles

V Estevez, M Villacampa, JC Menendez - Chemical Society Reviews, 2010 - pubs.rsc.org
Multicomponent reactions are one of the most interesting concepts in modern synthetic
chemistry and, as shown in this critical review, they provide an attractive entry into pyrrole …

Recognizing pitfalls in virtual screening: a critical review

T Scior, A Bender, G Tresadern… - Journal of chemical …, 2012 - ACS Publications
The aim of virtual screening (VS) is to identify bioactive compounds through computational
means, by employing knowledge about the protein target (structure-based VS) or known …

Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds

JD Sunderhaus, SF Martin - Chemistry–A European Journal, 2009 - Wiley Online Library
The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions
is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal …

The symbiotic relationship between drug discovery and organic chemistry

OO Grygorenko, DM Volochnyuk… - … A European Journal, 2020 - Wiley Online Library
All pharmaceutical products contain organic molecules; the source may be a natural product
or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry …

In situ click chemistry: probing the binding landscapes of biological molecules

SK Mamidyala, MG Finn - Chemical Society Reviews, 2010 - pubs.rsc.org
Combinatorial approaches to the discovery of new functional molecules are well established
among chemists and biologists, inspired in large measure by the modular composition of …

5-Ene-4-thiazolidinones–An efficient tool in medicinal chemistry

D Kaminskyy, A Kryshchyshyn, R Lesyk - European journal of medicinal …, 2017 - Elsevier
The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Eco-friendly functionalization of magnetic halloysite nanotube with SO3H for synthesis of dihydropyrimidinones

A Maleki, Z Hajizadeh, R Firouzi-Haji - Microporous and Mesoporous …, 2018 - Elsevier
In this work, the preparation of a new magnetic nanocomposite Fe 3 O 4-halloysite-SO 3 H
with nanotube morphology decorated by the spherical nanoparticles is reported …