Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Acinetobacter baumannii is a common cause of serious nosocomial infections. Although
community-acquired infections are observed, the vast majority occur in people with …

Highlights•Natural transformation mediates the spread of antibiotic resistance
genes.•Natural transformation can aid gene transfer between unrelated taxa.•Natural …

Tackling the challenge created by antibiotic resistance requires understanding the
mechanisms behind its evolution. Like any evolutionary process, the evolution of …

Antimicrobial resistance (AMR) represents a major challenge to global health. This problem
is most apparent in healthcare facilities, with a comparatively small number of pathogens …

The nosocomial pathogen Acinetobacter baumannii acquired clinical significance due to the
rapid development of its multi-drug resistant (MDR) phenotype. A. baumannii strains have …

Polymyxin B (PMB) is increasingly used as a last-line antibiotic; however, the emergence of
PMB resistance is a serious threat to global health. Here, a total of 40 Acinetobacter …

Acinetobacter baumannii A118, a strain isolated from the blood of an infected patient, is
naturally competent and unlike most clinical strains, is susceptible to a variety of different …

Bacterial infections routinely cause inflammation and thereby impair osseointegration of
orthopedic implants. Acinetobacter spp., which cause osteomyelitis following trauma, on or …

Bacteriophages play integral roles in the ecosystem; however, their precise involvement in
horizontal gene transfer and the spread of antibiotic resistance genes (ARGs) are not fully …