Migraine is a disabling neurological disorder, diagnosis of which is based on clinical criteria.
A shortcoming of these criteria is that they do not fully capture the heterogeneity of migraine …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Migraine is a complex disorder characterized by recurrent episodes of headache, and is one
of the most prevalent and disabling neurological disorders. A key feature of migraine is that …

Significance: Enhanced levels of reactive oxygen species (ROS) have been associated with
different disease states. Most attempts to validate and exploit these associations by chronic …

Calcitonin gene‐related peptide (CGRP) and metabolic products of nitric oxide (NO) are
increased in jugular venous plasma during migraine attacks and other primary headaches …

Migraine is a common neurological disorder often treated with triptans. Triptan overuse can
lead to increased frequency of headache in some patients, a phenomenon termed …

In vitro studies have contributed to the characterization of receptors in cranial blood vessels
and the identification of new possible anti-migraine agents. In vivo animal models enable …

Significance: Oxidative stress is suggested to be a disease mechanism common to a wide
range of disorders affecting human health. However, so far, the pharmacotherapeutic …

Background: Migraine is a primary headache disorder. Despite numerous studies conducted
with the aim to understand the pathophysiology of migraine, several aspects are still unclear …

Pain is a multidimensional perception and is modified at distinct regions of the neuroaxis.
During enhanced pain, neuroplastic changes occur in the spinal and supraspinal …