The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …

ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose
expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α …

Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma
differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

Mathematical modeling has been instrumental in identifying common principles of cell
polarity across diverse systems. These principles include positive feedback loops that are …

Summary The small GTPase RhoA is involved in a variety of fundamental processes in
normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing …

Maintenance of genome stability is a crucial priority for any organism. To meet this priority,
robust signalling networks exist to facilitate error-free DNA replication and repair. These …

We report here two genome-wide CRISPR screens performed to identify genes that, when
knocked out, alter levels of lysosomal cholesterol or bis (monoacylglycero) phosphate. In …

Background Our previous work showed that some Rho GTPases, including Rho, Rac1 and
Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC …

The metastatic spread of tumor cells to distant anatomical locations is a critical cause for
disease progression and leads to more than 90% of cancer-related deaths. IQ motif …