[HTML][HTML] Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis
D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …
[HTML][HTML] Transforming growth factor-β: a multifunctional regulator of cancer immunity
VW Xue, JYF Chung, CAG Córdoba, AHK Cheung… - Cancers, 2020 - mdpi.com
Simple Summary Transforming growth factor beta (TGF-β) is a multifunctional cytokine that
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …
can restrict cancer onset but also promote cancer progression at late stages of cancer. The …
[HTML][HTML] Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment
H Egan, O Treacy, K Lynch, NA Leonard, G O'Malley… - Cell Reports, 2023 - cell.com
Immunosuppressive tumor microenvironments (TMEs) reduce the effectiveness of immune
responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated …
responses in cancer. Mesenchymal stromal cells (MSCs), precursors to cancer-associated …
TWIST1 and TSG6 are coordinately regulated and function as potency biomarkers in human MSCs
RH Lee, SV Boregowda, T Shigemoto-Kuroda… - Science …, 2023 - science.org
Mesenchymal stem/stromal cells (MSCs) have been evaluated in> 1500 clinical trials, but
outcomes remain suboptimal because of knowledge gaps in quality attributes that confer …
outcomes remain suboptimal because of knowledge gaps in quality attributes that confer …
[HTML][HTML] The MSC-EV-microRNAome: a perspective on therapeutic mechanisms of action in sepsis and ARDS
Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have
emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory …
emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory …
[HTML][HTML] TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway
X Luan, P Chen, Y Li, X Yuan, L Miao, P Zhang… - Stem Cell Research & …, 2023 - Springer
Background Adipose tissue-derived stem cell (ADSC) transplantation has been shown to be
effective for the management of severe liver disorders. Preactivation of ADSCs enhanced …
effective for the management of severe liver disorders. Preactivation of ADSCs enhanced …
[HTML][HTML] Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies
J Wang, E Donohoe, A Canning… - International …, 2023 - Elsevier
Abstract Background Mesenchymal stromal cells (MSCs) show great potential for
immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for …
immunomodulatory and anti-inflammatory treatments. Clinical trials have been performed for …
[HTML][HTML] Adult tissue-specific stem cell interaction: novel technologies and research advances
X Luo, Z Liu, R Xu - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Adult tissue-specific stem cells play a dominant role in tissue homeostasis and regeneration.
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …
Various in vivo markers of adult tissue-specific stem cells have been increasingly reported …
[HTML][HTML] Intraarticular injections of mesenchymal stem cells in knee osteoarthritis: a review of their current molecular mechanisms of action and their efficacy
EC Rodríguez-Merchán - International Journal of Molecular Sciences, 2022 - mdpi.com
More than 10% of the world's population suffers from osteoarthritis (OA) of the knee, with a
lifetime risk of 45%. Current treatments for knee OA pain are as follows: weight control; oral …
lifetime risk of 45%. Current treatments for knee OA pain are as follows: weight control; oral …
[HTML][HTML] The inflammatory lung microenvironment; a key mediator in MSC licensing
H Dunbar, DJ Weiss, S Rolandsson Enes, JG Laffey… - Cells, 2021 - mdpi.com
Recent clinical trials of mesenchymal stromal cell (MSC) therapy for various inflammatory
conditions have highlighted the significant benefit to patients who respond to MSC …
conditions have highlighted the significant benefit to patients who respond to MSC …