The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

The metastatic process of colorectal cancer (CRC) is not fully understood and effective
therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal …

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. Despite
recent advances in the molecular genetics of CRC, poor treatment outcomes highlight the …

Colorectal cancer (CRC) is known as the third most common cancer as well as the fourth
most deadly cancer worldwide. CRC accounts for approximately 10% of all new cancer …

Colorectal cancers (CRCs) can be divided into four gene expression-based biologically
distinct consensus molecular subtypes (CMS). This classification provides a potential …

The composition of the intestinal microbiota is associated with both the development of
tumors and the efficacy of anti-tumor immunity. Here, we examined the impact of microbiota …

Colorectal cancer (CRC) is a serious public health issue, and it has the leading incidence
and mortality among malignant tumors worldwide. CRC patients with metastasis in the liver …

Metastasis is the primary cause of cancer-related mortality in colorectal cancer (CRC)
patients. How to improve therapeutic options for patients with metastatic CRC is the core …

KRAS is one of the most frequently mutated oncogenes in cancer, being a potent initiator of
tumorigenesis, a strong inductor of malignancy, and a predictive biomarker of response to …