Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Hyperspectral imaging (HSI) and multispectral imaging (MSI) technologies have the
potential to transform the fields of digital and computational pathology. Traditional digitized …

Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

Background Conventional immunohistochemistry technologies were limited by the inability
to simultaneously detect multiple markers and the lack of identifying spatial relationships …

Hyperspectral fluorescence imaging (HFI) is a well-known technique in the medical research
field and is considered a non-invasive tool for tissue diagnosis. This review article gives a …

Non-small cell lung cancer (NSCLC) is a serious threat to the health of older adults. Despite
the significant progress in immunotherapy, effective treatments for NSCLC remain limited …

The Immunoscore is a method to quantify the immune cell infiltration within cancers to
predict the disease prognosis. Previous immune profiling approaches relied on limited …

Abstract Background Anti-PD-(L) 1 immunotherapy has been recommended for non-small
cell lung cancer (NSCLC) patients with lymph node metastases (LNM). However, the exact …

There is increasing evidence that the spatial organization of cells within the tumor-immune
microenvironment (TiME) of solid tumors influences survival and response to therapy in …

Simple Summary Immune modulation is considered a hallmark of cancer initiation and
progression, and has offered promising opportunities for therapeutic manipulation. Multiplex …