Macropinocytosis: mechanisms and regulation
G Salloum, AR Bresnick, JM Backer - Biochemical Journal, 2023 - portlandpress.com
Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …
Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins
S Suetsugu, S Kurisu, T Takenawa - Physiological reviews, 2014 - journals.physiology.org
All cellular compartments are separated from the external environment by a membrane,
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
which consists of a lipid bilayer. Subcellular structures, including clathrin-coated pits …
Functions and regulation of circular dorsal ruffles
JL Hoon, WK Wong, CG Koh - Molecular and cellular biology, 2012 - Taylor & Francis
Cells construct a number of plasma membrane structures to meet a range of physiological
demands. Driven by juxtamembrane actin machinery, these actin-based membrane …
demands. Driven by juxtamembrane actin machinery, these actin-based membrane …
Arf proteins in cancer cell migration
Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
Mass spectrometry and imaging analysis of nanoparticle-containing vesicles provide a mechanistic insight into cellular trafficking
D Hofmann, S Tenzer, MB Bannwarth… - Acs Nano, 2014 - ACS Publications
Rational design of nanocarriers for drug delivery approaches requires an unbiased
knowledge of uptake mechanisms and intracellular trafficking pathways. Here we dissected …
knowledge of uptake mechanisms and intracellular trafficking pathways. Here we dissected …
Charming neighborhoods on the cell surface: plasma membrane microdomains regulate receptor tyrosine kinase signaling
RCD Santos, C Garay, CN Antonescu - Cellular signalling, 2015 - Elsevier
Receptor tyrosine kinases (RTK) are an important family of growth factor and hormone
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …
receptors that regulate many aspects of cellular physiology. Ligand binding by RTKs at the …
Arf GAPs as regulators of the actin cytoskeleton—an update
CE Tanna, LB Goss, CG Ludwig, PW Chen - International journal of …, 2019 - mdpi.com
Arf GTPase-activating proteins (Arf GAPs) control the activity of ADP-ribosylation factors
(Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both …
(Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both …
Fronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
E Bernitt, HG Döbereiner, NS Gov… - Nature Communications, 2017 - nature.com
During macropinocytosis, cells remodel their morphologies for the uptake of extracellular
matter. This endocytotic mechanism relies on the collapse and closure of precursory …
matter. This endocytotic mechanism relies on the collapse and closure of precursory …
The effect of lncRNA‐ARAP1‐AS2/ARAP1 on high glucose‐induced cytoskeleton rearrangement and epithelial–mesenchymal transition in human renal tubular …
L Li, L Xu, S Wen, Y Yang, X Li… - Journal of Cellular …, 2020 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) plays an important role in diabetic renal
fibrosis. The ARAP1 gene is located near risk alleles for Type 2 diabetes, and its function …
fibrosis. The ARAP1 gene is located near risk alleles for Type 2 diabetes, and its function …
LncRNA ARAP1‐AS2 promotes high glucose‐induced human proximal tubular cell injury via persistent transactivation of the EGFR by interacting with ARAP1
X Li, TK Ma, S Wen, LL Li, L Xu, XW Zhu… - Journal of Cellular …, 2020 - Wiley Online Library
The persistent transactivation of epidermal growth factor receptor (EGFR) causes
subsequent activation of the TGF‐β/Smad3 pathway, which is closely associated with …
subsequent activation of the TGF‐β/Smad3 pathway, which is closely associated with …