Sarcopenia, which is characterized by the loss of skeletal muscle, has been reported to
contribute to development of physical disabilities, various illnesses, and increasing mortality …

MicroRNAs (miRNAs) regulate gene expression via transcript degradation and translational
inhibition, and they may also function as long distance signaling molecules. Circulatory …

Exercise has multi-systemic benefits and attenuates the physiological impairments
associated with aging. Emerging evidence suggests that circulating exosomes mediate …

Humanin is a small regulatory peptide encoded within the 16S ribosomal RNA gene (MT-
RNR2) of the mitochondrial genome that has cellular cyto-and metabolo-protective …

Mitochondria putatively regulate the aging process, in part, through the small regulatory
peptide, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) that is encoded by …

The ratio of fast-and slow-twitch fibers in human skeletal muscle is variable and largely
determined by genetic factors. In this study, we investigated the contribution of microRNA …

In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary
elderly and from age-matched athletes with an exceptional record of high-intensity, life-long …

Aims Exercise training is a powerful adjunctive therapy in patients with heart failure with
reduced ejection fraction (HFrEF), but ca. 55% of patients fail to improve VO2peak. We …

Purpose Lifelong exercise is known to attenuate sarcopenia (age-associated reduction in
muscle mass and function); however, the underlying molecular mechanisms remain unclear …

MicroRNAs (miRNAs) play an essential role in many biological processes. In this study,
miRNAs in the skeletal muscle of normal and intrauterine growth retardation (IUGR) …