Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
[HTML][HTML] Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics
Sexual dimorphism refers to differences between biological sexes that extend beyond
sexual characteristics. In humans, sexual dimorphism in the immune response has been …
sexual characteristics. In humans, sexual dimorphism in the immune response has been …
DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
[HTML][HTML] The roles of epigenetics regulation in bone metabolism and osteoporosis
F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a metabolic disease characterized by decreased bone mineral density and
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
the destruction of bone microstructure, which can lead to increased bone fragility and risk of …
eIF2α signaling regulates autophagy of osteoblasts and the development of osteoclasts in OVX mice
J Li, X Li, D Liu, K Hamamura, Q Wan, S Na… - Cell Death & …, 2019 - nature.com
Bone loss in postmenopausal osteoporosis is induced chiefly by an imbalance of bone-
forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that …
forming osteoblasts and bone-resorbing osteoclasts. Salubrinal is a synthetic compound that …
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies
L Qi, AE Teschendorff - Clinical Epigenetics, 2022 - Springer
Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …
composed of many different cell-types. By definition, these cell-types vary substantially in …
Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders
Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …
and mortality. The variety of metabolic illnesses can be addressed through personalized …
Role of epigenomics in bone and cartilage disease
JBJ van Meurs, CG Boer… - Journal of Bone and …, 2019 - academic.oup.com
Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …
environmental factors. Epigenetic mechanisms include information‐containing factors, other …
The aging skeleton
D Goltzman - Human Cell Transformation: Advances in Cell Models …, 2019 - Springer
Skeletal aging begins after peak bone mass is reached; progressive bone loss then occurs.
Peak bone mass may occur at different ages in different skeletal sites and varies between …
Peak bone mass may occur at different ages in different skeletal sites and varies between …
Gender-affirming hormone therapy induces specific DNA methylation changes in blood
Background DNA methylation is an epigenetic mark that is influenced by underlying genetic
profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific …
profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific …