Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Hemochorial placentation is orchestrated through highly regulated temporal and spatial
decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell …

Hypoxia may influence normal and different pathological processes. Low oxygenation
activates a variety of responses, many of them regulated by hypoxia‐inducible factor 1 …

Fetal growth retardation is a fetal adaptation in response to inadequate supply of oxygen
and/or nutrients. Animal models of intrauterine growth retardation are an invaluable tool to …

Hypoxia is necessary for fetal development; however, excess hypoxia is detrimental.
Hypoxia has been extensively studied in the near-term fetus, but less is known about earlier …

When oxygen demand is greater than oxygen supply, cells need to rapidly adjust their
metabolism in order for the tissue to survive. Oxygen sensing by an organism influences a …

In the Western world, cardiovascular disease, along with diabetes mellitus and its
complications, are leading causes of death. A number of important risk factors have been …

Insulin-like growth factor binding protein 1 (IGFBP-1) is a hypoxia-inducible gene that plays
an important role in regulating embryonic growth and development under hypoxic stress …

Neurodevelopmental changes may underlie the brain dysfunction seen in schizophrenia.
While advances have been made in our understanding of the genetics of schizophrenia …