In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a
promising treatment for diabetes. Despite progress in the generation of stem-cell-derived …

Diabetes is the most common metabolic disorder, with an extremely serious effect on health
systems worldwide. It has become a severe, chronic, non-communicable disease after …

Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle play key roles in nutrient-
stimulated K ATP channel closure and insulin secretion. To identify the PK isoforms …

The dysfunction of pancreatic β-cells plays a central role in the onset and progression of
type 2 diabetes mellitus (T2DM). Insulin secretory defects in β-cells are characterized by a …

Summary The ATP-sensitive K+(K ATP) channel is a key regulator of hormone secretion
from pancreatic islet endocrine cells. Using direct measurements of K ATP channel activity in …

The mitochondrial GTP (mtGTP)-dependent phosphoenolpyruvate (PEP) cycle couples
mitochondrial PEPCK (PCK2) to pyruvate kinase (PK) in the liver and pancreatic islets to …

Pancreatic islets regulate blood glucose homeostasis through the controlled release of
insulin; however, current metabolic models of glucose-sensitive insulin secretion are …

We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay
between increased oxidative stress and excess lipid in the form of reactive oxygen species …