Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that
induce the ternary complex formation between a protein-of-interest (POI) and an E3 ligase …

A striking example of topographic specificity in synapse formation is the preferential
reinnervation of original synaptic sites on denervated muscle fibres by regenerating motor …

Proteolysis‐targeting chimeras (PROTACs) is a targeted protein degradation (TPD)
technique effected by hijacking the ubiquitin‐proteasome system (UPS) of the cells. A …

Context-specific targeting of the androgen receptor in prostate cancer | Nature Genetics
Skip to main content Thank you for visiting nature.com. You are using a browser version …

Decades of biological and clinical research have led to important advances in recombinant
adeno-associated viruses rAAV-based gene therapy gene therapy. However, several …

Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer with a dismal
overall prognosis. NSD2 is an H3K36‐specific di‐methyltransferase that has been reported …

The organization of a cell membrane is vital for various functions, such as receptor signaling
and membrane traffic. However, the understanding of membrane organization remains …

Spectrin, the principal protein of the cytoskeleton of erythrocyte, plays a crucial role in the
stability and flexibility of the plasma membrane of erythrocyte. In this work, we investigate the …

Direct visualization of co-translational folding of nascent polypeptide chains is challenging.
Here we present, for the first time, AFM images of large protein constructs based on the …

THE PHD5-C5HCH TANDEM DOMAINS OF NSD PROTEINS ARE STRUCTURAL HUBS FOR
THE INTERACTIONS WITH THE CO-REPRESSOR NIZP1 AND THE HISTONE H3 TAIL. Page …