Older adult participation in cancer clinical trials: a systematic review of barriers and interventions

MS Sedrak, RA Freedman, HJ Cohen… - CA: a cancer journal …, 2021 - Wiley Online Library
Cancer is a disease of aging and, as the world's population ages, the number of older
persons with cancer is increasing and will make up a growing share of the oncology …

Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists …

L Biganzoli, NML Battisti, H Wildiers… - The Lancet …, 2021 - thelancet.com
Breast cancer is increasingly prevalent in older adults and is a substantial part of routine
oncology practice. However, management of breast cancer in this population is challenging …

Geriatric assessment–driven intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial

D Li, CL Sun, H Kim, E Soto-Perez-de-Celis… - JAMA …, 2021 - jamanetwork.com
Importance Although geriatric assessment–driven intervention improves patient-centered
outcomes, its influence on chemotherapy-related toxic effects remains unknown. Objective …

How is geriatric assessment used in clinical practice for older adults with cancer? A survey of cancer providers by the American Society of Clinical Oncology

W Dale, GR Williams, A R. MacKenzie… - JCO oncology …, 2021 - ascopubs.org
PURPOSE: For patients with cancer who are older than 65 years, the 2018 ASCO Guideline
recommends geriatric assessment (GA) be performed. However, there are limited data on …

Geriatric assessment and management in cancer

S Rostoft, A O'Donovan, P Soubeyran… - Journal of Clinical …, 2021 - ascopubs.org
As the majority of patients with cancer are older than 65 years, most medical, surgical, and
radiation oncologists treat a large number of older adults in their clinical practice. Older …

Development and validation of a risk tool for predicting severe toxicity in older adults receiving chemotherapy for early-stage breast cancer

A Magnuson, MS Sedrak, CP Gross, WP Tew… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Limited tools exist to predict the risk of chemotherapy toxicity in older adults with
early-stage breast cancer. METHODS Patients of age≥ 65 years with stage I-III breast …

Decision making in older adults with cancer

C DuMontier, KP Loh… - Journal of Clinical …, 2021 - ascopubs.org
Significant progress has been made toward improving the care of older adults with cancer.
As described elsewhere in this Special Series, the evidence base in geriatric oncology has …

Polypharmacy, potentially inappropriate medications, and drug-drug interactions in vulnerable older adults with advanced cancer initiating cancer treatment

E Ramsdale, M Mohamed, V Yu, E Otto, K Juba… - The …, 2022 - academic.oup.com
Purpose Polypharmacy is prevalent in older adults starting cancer treatment and associated
with potentially inappropriate medications (PIM), potential drug-drug interactions (DDI), and …

Older adults with cancer and their caregivers—current landscape and future directions for clinical care

S Kadambi, KP Loh, R Dunne, A Magnuson… - Nature Reviews …, 2020 - nature.com
Despite substantial improvements in the outcomes of patients with cancer over the past two
decades, older adults (aged≥ 65 years) with cancer are a rapidly increasing population and …

The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO)

CM Lund, KK Vistisen, AP Olsen, P Bardal… - British journal of …, 2021 - nature.com
Background Older patients with colorectal cancer (CRC) experience chemotherapy dose
reductions or discontinuation. Comprehensive geriatric assessment (CGA) predicts survival …