Type 1 diabetes mellitus (T1DM) and other chronic diseases in children are well known to
adversely affect linear growth and pubertal development. In the years immediately following …

Ensuring normal linear growth is one of the major therapeutic aims in the management of
type one diabetes mellitus (T1DM) in children and adolescents. Many studies in the …

Children and adolescents with chronic diseases are commonly affected by a variable
degree of growth failure, leading to an impaired final height. Of note, the peculiar onset …

Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF
binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism …

Type 1 diabetes mellitus (T1DM) has a significant effect on the growth of children. The
disease has a negative effect on growth when considered in relation to the time period and …

Measurements of circulating insulin-like growth factor-I (IGF-I) levels are an important part of
many studies on growth and development. Circulating IGF-I levels are growth hormone (GH) …

Semi-quantitative neuroradiologic studies, quantitative neuron density studies and
immunocytochemistry markers of oxidative stress and neuroinflammation indicate neuronal …

Data on growth of children with insulin-dependent diabetes mellitus (IDDM) before the onset
of disease are conflicting, and although the insulin-like growth factor (IGF) system has …

Increasing evidence suggests a role of the IGF axis in the maintenance of normal glucose
and lipid metabolism. The local IGF-IGFBP environment changes significantly in response to …

The IGF system plays vital roles in neuronal development, metabolism, regeneration and
survival. It consists of IGF‐I, IGF‐II, insulin, IGF‐I‐receptor, and those of IGF‐II and insulin as …