Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer. NEPC arises
de novo only rarely; the disease predominantly develops from adenocarcinoma in response …

The recent outbreak of infections and the pandemic caused by SARS-CoV-2 represent one
of the most severe threats to human health in more than a century. Emerging data from the …

Prostate cancer rates vary substantially by race, ethnicity, and geography. These disparities
can be explained by variation in access to screening and treatment, variation in exposure to …

Since the introduction of serum prostate-specific antigen (PSA) screening 25 years ago,
prostate cancer diagnosis and management have been guided by this biomarker. Yet, PSA …

Background Prostate cancer antigen 3 (PCA3) and v-ets erythroblastosis virus E26
oncogene homolog (TMPRSS2-ERG) gene fusions are promising prostate cancer (PCa) …

ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

Rare circulating tumor cells (CTCs) are present in the blood of patients with metastatic
epithelial cancers but have been difficult to measure routinely. We report a quantitative …

TMPRSS2-ERG gene fusions are the predominant molecular subtype of prostate cancer.
Here, we explored the role of TMPRSS2-ERG gene fusion product using in vitro and in vivo …

Prostate cancer is the most prevalent non-skin cancer in men and is the leading cause of
cancer-related death. Early detection of prostate cancer is largely determined by a widely …

Recently, we identified recurrent gene fusions involving the 5′ untranslated region of the
androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family …