The cell-cell adhesion molecule E-cadherin

F Van Roy, G Berx - Cellular and molecular life sciences, 2008 - Springer
This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule
with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As …

[HTML][HTML] Structural and signaling functions of integrins

YA Kadry, DA Calderwood - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

Leaving the neighborhood: molecular mechanisms involved during epithelial‐mesenchymal transition

P Savagner - Bioessays, 2001 - Wiley Online Library
Several molecular mechanisms contribute directly and mechanically to the loss of epithelial
phenotype. During epithelial–mesenchymal transition (EMT), adherens junctions and …

Inhibition of LFA‐1/ICAM‐1 and VLA‐4/VCAM‐1 as a therapeutic approach to inflammation and autoimmune diseases

H Yusuf‐Makagiansar, ME Anderson… - Medicinal research …, 2002 - Wiley Online Library
This review focuses on providing insights into the structural basis and clinical relevance of
LFA‐1 and VLA‐4 inhibition by peptides and small molecules as adhesion‐based …

Development and functional specialization of CD103+ dendritic cells

ML Del Rio, G Bernhardt… - Immunological …, 2010 - Wiley Online Library
CD103 (αE) integrin expression distinguishes a population of dendritic cells (DCs) that can
be found in many if not all lymphoid and non‐lymphoid organs. CD103+ DCs display distinct …

The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion

TA Springer, JH Wang - Advances in protein chemistry, 2004 - Elsevier
Integrins are a structurally elaborate family of adhesion molecules that transmit signals
bidirectionally across the plasma membrane by undergoing large-scale structural …

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

JP Evans - Bioessays, 2001 - Wiley Online Library
One of the most important cell–cell interactions is that of the sperm with the egg. This
interaction, which begins with cell adhesion and culminates with membrane fusion, is …

T-lymphocyte–epithelial-cell interactions: integrin αE (CD103) β7, LEEP-CAM and chemokines

WW Agace, JMG Higgins, B Sadasivan… - Current opinion in cell …, 2000 - Elsevier
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces
of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the …

The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism

E Parisini, JMG Higgins, J Liu, MB Brenner… - Journal of molecular …, 2007 - Elsevier
Cell adhesion mediated by type I cadherins involves homophilic “trans” interactions that are
thought to be brought about by a strand exchange mechanism involving the N-terminal …

Gut-selective integrin-targeted therapies for inflammatory bowel disease

CA Lamb, S O'Byrne, ME Keir… - Journal of Crohn's and …, 2018 - academic.oup.com
Integrins are cell surface receptors with bidirectional signalling capabilities that can bind to
adhesion molecules in order to mediate homing of leukocytes to peripheral tissues. Gut …