ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas

S Hong, PL Pedersen - Microbiology and molecular biology …, 2008 - Am Soc Microbiol
SUMMARY ATP synthase, a double-motor enzyme, plays various roles in the cell,
participating not only in ATP synthesis but in ATP hydrolysis-dependent processes and in …

ATP synthase: a molecular therapeutic drug target for antimicrobial and antitumor peptides

Z Ahmad, F Okafor, S Azim… - Current medicinal …, 2013 - ingentaconnect.com
In this review we discuss the role of ATP synthase as a molecular drug target for natural and
synthetic antimicrobial/antitumor peptides. We start with an introduction of the universal …

Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner

N Chinnam, PK Dadi, SA Sabri, M Ahmad… - International journal of …, 2010 - Elsevier
The aim of this study was to determine if the dietary benefits of bioflavonoids are linked to
the inhibition of ATP synthase. We studied the inhibitory effect of 17 bioflavonoid compounds …

Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase

V Kabaleeswaran, N Puri, JE Walker… - The EMBO …, 2006 - embopress.org
The crystal structure of yeast mitochondrial F1 ATPase contains three independent copies of
the complex, two of which have similar conformations while the third differs in the position of …

Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols

PK Dadi, M Ahmad, Z Ahmad - International Journal of Biological …, 2009 - Elsevier
We have studied the inhibitory effect of five polyphenols namely, resveratrol, piceatannol,
quercetin, quercetrin, and quercetin-3-β-d glucoside on Escherichia coli ATP synthase …

[HTML][HTML] A structure-based model for the synthesis and hydrolysis of ATP by F1-ATPase

YQ Gao, W Yang, M Karplus - Cell, 2005 - cell.com
Many essential functions of living cells are performed by nanoscale protein motors. The best
characterized of these is F o F 1-ATP synthase, the smallest rotary motor. This rotary motor …

Futile cycling increases sensitivity toward oxidative stress in Escherichia coli

KJ Adolfsen, MP Brynildsen - Metabolic engineering, 2015 - Elsevier
Reactive oxygen species (ROS) are toxic molecules utilized by the immune system to
combat invading pathogens. Recent evidence suggests that inefficiencies in ATP production …

A therapeutic connection between dietary phytochemicals and ATP synthase

Z Ahmad, SS Hassan, S Azim - Current medicinal chemistry, 2017 - ingentaconnect.com
For centuries, phytochemicals have been used to prevent and cure multiple health ailments.
Phytochemicals have been reported to have antioxidant, antidiabetic, antitussive …

Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth

Z Ahmad, TF Laughlin, IO Kady - PLoS One, 2015 - journals.plos.org
We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO
E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely …

Inhibition of Escherichia coli ATP synthase by dietary ginger phenolics

T Hughes, S Azim, Z Ahmad - International Journal of Biological …, 2021 - Elsevier
For centuries, dietary ginger has been known for its antioxidant, anticancer, and antibacterial
properties. In the current study, we examined the link between antibacterial properties of 7 …