Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Various adverse events resulting from, or associated with, benzodiazepine and/or Z-drug
use have been extensively reported on and discussed in great detail within the biomedical …

Insomnia is present in up to one third of the adult population worldwide, and it can present
independently or with other medical conditions such as mental, metabolic, or cardiovascular …

Objective zolpidem, zopiclone, eszopiclone and zaleplon, also known as 'Z-drugs', are
commonly used as alternatives to benzodiazepines (BZDs) to treat insomnia. Z-drugs are …

Importance Although overall rates of opioid use have been plateauing, coprescriptions of
benzodiazepines and opioids have increased greatly in recent years. It is unknown whether …

Dual orexin receptor antagonists (DORAs) represent a novel type of sleep medication that
provide an alternative to the traditionally used positive allosteric gamma-aminobutyric acid …

Study Objectives: Heart attacks and motor vehicle crashes are the leading causes of death
in US firefighters. Given that sleep disorders are an independent risk factor for both of these …

A new mononuclear tetrahedral CoII complex, dichloridobis (imidazo [1, 2-a] pyridine-κN1)
cobalt (II),[CoCl2 (C7H6N2) 2], has been synthesized using a bioactive imidazopyridine …

Falls in the elderly represent a major health problem. The etiology of falls is usually
multifactorial. Special attention should be paid on benzodiazepines (BZDs) since they are …

Since its discovery in 1998, the orexin system, composed of two G-protein coupled
receptors, orexins 1 and 2, and two neuropeptide agonists, orexins A and B, has captured …