Molecular imaging and disease theranostics with renal-clearable optical agents

P Cheng, K Pu - Nature Reviews Materials, 2021 - nature.com
Optical imaging in disease diagnosis and treatment benefits from high spatiotemporal
resolution and the availability of numerous optical agents. However, many optical imaging …

From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

M Gao, F Yu, C Lv, J Choo, L Chen - Chemical Society Reviews, 2017 - pubs.rsc.org
Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

A neurocentric perspective on glioma invasion

VA Cuddapah, S Robel, S Watkins… - Nature Reviews …, 2014 - nature.com
Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Molecular interactions in organic nanoparticles for phototheranostic applications

KK Ng, G Zheng - Chemical reviews, 2015 - ACS Publications
Optical and photonic technologies play an important role in human progress. The bending of
light to our will has not only enabled our biological self-discovery, but has also allowed us to …

CAR T cells for brain tumors: Lessons learned and road ahead

D Akhavan, D Alizadeh, D Wang, MR Weist… - Immunological …, 2019 - Wiley Online Library
Malignant brain tumors, including glioblastoma, represent some of the most difficult to treat
of solid tumors. Nevertheless, recent progress in immunotherapy, across a broad range of …

Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

D Wang, R Starr, WC Chang, B Aguilar… - Science translational …, 2020 - science.org
Although chimeric antigen receptor (CAR) T cells have demonstrated signs of antitumor
activity against glioblastoma (GBM), tumor heterogeneity remains a critical challenge. To …

[HTML][HTML] Peptide therapeutics from venom: Current status and potential

MW Pennington, A Czerwinski, RS Norton - Bioorganic & medicinal …, 2018 - Elsevier
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

Protein− nanoparticle interactions: opportunities and challenges

M Mahmoudi, I Lynch, MR Ejtehadi… - Chemical …, 2011 - ACS Publications
In recent years, the fabrication of nanomaterials and exploration of their properties have
attracted the attention of all branches of science, such as physics, chemistry, biology, and …

Fluorescence-guided surgery with live molecular navigation—a new cutting edge

QT Nguyen, RY Tsien - Nature reviews cancer, 2013 - nature.com
A glowing new era in cancer surgery may be dawning. Using fluorescently labelled markers,
surgical molecular navigation means that tumours and nerves can be displayed in real time …