Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and
significant health problem in the United States and worldwide. The mechanisms contributing …

Objectives: Increasing body of experimental and clinical data indicates that early brain injury
after initial bleeding largely contributes to unfavorable outcome after subarachnoid …

VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Subarachnoid hemorrhage (SAH) is a devastating stroke subtype with a high rate of
mortality and morbidity. The poor clinical outcome can be attributed to the biphasic course of …

Large conductance Ca2+-activated K+ (BKCa) channels are abundantly expressed in
vascular smooth muscle cells. Activation of BKCa channels leads to hyperpolarization of cell …

The elusive nature of events that sustain cerebral vasospasm after subarachnoid
hemorrhage resulting from a ruptured aneurysm presents major challenges in designing …

Abstracts Voltage-gated K+ channels (K v) play an important role in regulating contraction of
vascular smooth muscle cells (VSMC) through their effects on membrane potential and on …

Large conductance calcium-dependent (Slo1 BK) channels are allosterically activated by
membrane depolarization and divalent cations, and possess a rich modulatory repertoire …

More than 20 years of research on heme as a temporary effector molecule of proteins have
revealed its widespread impact on virtually all primary functions in the human organism. As …