The role of structurally dynamic genomic regions in speciation is poorly understood due to
challenges inherent in diploid genome assembly. Here we reconstructed the evolutionary …

Histone post-translational modifications, such as phosphorylation, methylation, acetylation,
and ubiquitination, play vital roles in various chromatin-based cellular processes. Meiosis is …

Spermatogenesis in the Drosophila male germline proceeds through a unique
transcriptional program controlled both by germline-specific transcription factors and by …

Dynamic nuclear architecture and chromatin organizations are the key features of the mid‐
prophase I in mammalian meiosis. The chromatin undergoes major changes, including …

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I
progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of …

Hybrids between closely related but genetically incompatible species are often inviable or
sterile. Cattle-yak, an interspecific hybrid of yak and cattle, exhibits male-specific sterility …

Hybrid incompatibilities are a critical component of species barriers and may arise due to
negative interactions between divergent regulatory elements in parental species. We used a …

The transcriptional dynamic of mammalian cells when these transit from the ubiquitous
mitotic to a meiotic specific program is key to understand this switch central to sexual …

The male germline of Drosophila melanogaster is a powerful system for investigating
chromatin regulation in a differentiating tissue. Testis-specific genes utilize a distinct system …

Abstract H3K9 trimethylation (H3K9me3) plays emerging roles in gene regulation, beyond
its accumulation on pericentric constitutive heterochromatin. It remains a mystery why and …