Modular synthesis of functional libraries by accelerated SuFEx click chemistry

JA Homer, RA Koelln, AS Barrow, TL Gialelis… - Chemical …, 2024 - pubs.rsc.org
Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl
alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and …

Intramolecular chalcogen bonding activated SuFEx click chemistry for efficient organic-inorganic linking

M Wang, J Hou, H Do, C Wang, X Zhang, Y Du… - Nature …, 2024 - nature.com
SuFEx click chemistry demonstrates remarkable molecular assembly capabilities. However,
the effective utilization of alkyl sulfonyl fluoride hubs in SuFEx chemistry, particularly in …

Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development

L Yang, Z Yuan, Y Li, S Yang, B Yu - Medicinal Chemistry Research, 2024 - Springer
Sulfur (VI) fluoride exchange (SuFEx), a new generation of click chemistry, enables the
creation of a stable covalent linkage between a protein and its interacting biomolecule. This …

Radical Ring-Opening Fluorosulfonylation of Methylenecyclobutanols via Electron Donor–Acceptor Photoactivation

T He, C Liang, P Jiang, H Liang, S Liao… - Organic Letters, 2024 - ACS Publications
A visible-light-mediated catalyst-and additive-free method for radical ring-opening
fluorosulfonylation of methylenecyclobutanols is reported. Sulfuryl chlorofluoride acts as a …

Fe-Catalyzed Fluorosulfonylation of Alkenes via Sulfur Dioxide Insertion: Synthesis of Lactam-Functionalized Alkyl Sulfonyl Fluorides

DZ Sun, X Hu, F Long, CC Peng, KY Zhang, Q Li… - Organic …, 2024 - ACS Publications
A novel Fe-catalyzed fluorosulfonylation of alkenes with Na2S2O4 and N-
fluorobenzenesulfonimide (NFSI) for assembling various lactam-functionalized alkyl sulfonyl …

Application of Sulfonyl Fluorides in Organic Transformation

S Wang, C Zhou, Y Han, M Li, C Ke, S Huang - Synthesis, 2024 - thieme-connect.com
ulfonyl fluorides, due to their balanced potential reactivity and stability as well as their
compatibility with biological systems, have become important synthetic intermediates and …

Recyclable 2-Fluoropyridine Derivative as a Storage for Highly Electrophilic 1, 1-Bis (triflyl) ethylene

H Yanai, S Hoshikawa, H Watanabe… - Chemical and …, 2024 - jstage.jst.go.jp
As an easy-to-handle reagent for the in situ generation of outstandingly electrophilic Tf 2 C=
CH 2 (Tf= CF 3 SO 2), we have designed and synthesised a novel 4-substituted 2 …

4-Vinylbenzenesulfonyl fluoride (VBSF): a highly reactive monomer for RAFT polymerization and exhaustive SuFEx postpolymerization sulfonamidation

Y Zhang, P Ma, W Bin, CM Plummer, Y Zhang - 2024 - chemrxiv.org
We designed and synthesized a 4-fluorosulfonyl styrene monomer, 4-vinylbenzenesulfonyl
fluoride (VBSF), for the evaluation of the efficiency of our catalytic sulfonamidation of sulfonyl …

Design of New Click Reagents and Mechanistic Insights on Aspartic Proteases

MAM Feliciano - 2024 - search.proquest.com
The control of (bio) chemical processes is fundamental to achieving desired outcomes. In
synthetic processes, inadequate selectivity and stability of reagents can hamper their …

Single-Atom Ligation of Four Different Alcohols at One Silicon Center: Methodology Development and Proof of Concept

C Wang, X Xu, X Zhang, H Lin, P Amin, Y Wang - 2024 - chemrxiv.org
Click chemistry continues to impact the chemistry and biology community, with the most well-
known being the CuAAC click chemistry. Topologically, the CuAAC click chemistry only …