Cellular oxidation–reduction (redox) systems, which encompass pro‐and antioxidant
molecules, are integral components of a plethora of essential cellular processes. Any …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Epstein–Barr virus (EBV) was the first oncogenic virus identified in humans. It is primarily
associated with multiple lymphoid and epithelial cancers, including nasopharyngeal …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved
cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides …

Peroxiredoxins (PRDX s), a ubiquitous family of redox‐regulating proteins, are reported of
potential to eliminate various reactive oxygen species (ROS). As a major member of the …

Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are
accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of …

Abstract p38 mitogen-activated protein kinases (P38α and β) and c-Jun N-terminal kinases
(JNK1, 2, and 3) are key mediators of the cellular stress response. However, prolonged P38 …

Peroxiredoxins (Prdxs) are a family of small (22-27kDa) non-seleno peroxidases currently
known to possess six mammalian isoforms. Although their individual roles in cellular redox …

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …