Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

HI Ahmed, EA Mohamed - Journal of biochemical and …, 2019 - Wiley Online Library
This study pointed to estimate the possible protective impacts of candesartan and/or
epigallocatechin‐3‐gallate (EGCG) against gentamicin‐induced nephrotoxicity. The current …

Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers

Z Halici, B Polat, E Cadirci, A Topcu, E Karakus… - Chemico-biological …, 2016 - Elsevier
Purpose Previously blocking the renin angiotensin system (RAAS) has been effective in the
prevention of gastric damage. Therefore, the aim of this study was to investigate the effects …

[HTML][HTML] Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina

T Narimatsu, Y Ozawa, S Miyake, N Nagai… - Free Radical Biology and …, 2014 - Elsevier
Exposure to light contributes to the development and progression of retinal degenerative
diseases. However, the mechanisms underlying light-induced tissue damage are not fully …

[PDF][PDF] Targeting oxidative stress and inflammation in NSAIDs induced gastropathy: a plausible therapeutic approach

K Sinha, PC Sil - Inflamm Cell Signal, 2015 - pdfs.semanticscholar.org
Deregulation in prostaglandin (PG) biosynthesis, oxidative stress, inflammation, and
apoptosis play a major role in the pathogenesis of nonsteroidal anti-inflammatory drug …

Duloxetine protected indomethacin-induced gastric mucosal injury by increasing serotonin-dependent RANTES expression and activating PI3K-AKT-VEGF pathway

H Ding, Y Wang, Y Gao, F Ye, K Yao, L Cao… - Toxicology and Applied …, 2024 - Elsevier
Antidepressant duloxetine has been shown protective effect on indomethacin-induced
gastric ulcer, which was escorted by inflammation in the gastric mucosa. Cytokines are the …

Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers

J Zhang, ZL Fu, ZX Chu… - … Based Complementary and …, 2020 - Wiley Online Library
Background. Abelmoschus manihot (L.) Medic flower is a medicinal plant for the treatment of
diseases in China. The present study was carried out to scientifically validate the …

Molecular Mechanisms of Clozapine-Induced Pancreatic Damage and its Modulation by L-Carnitine in a Rat Model

DIA Mesallam, E Ahmed Alaa El-Din… - Egyptian Society of …, 2024 - journals.ekb.eg
Background: Clozapine (CLZ) has been considered the mainstay drug in treatment of
resistant schizophrenia. Diabetes mellitus has befallen during clozapine therapy. L-carnitine …

Gastroprotective effects of Taraxacum officinale (Dandelion) extract indomethacin-induced gastric ulcer model

U Hamit, GA USLU - GSC Biological and Pharmaceutical …, 2022 - gsconlinepress.com
In this study, it was aimed to investigate the gastroprotective and anti-inflammatory effects of
the extract (TO) obtain from the leaves of Taraxacum officinale, which is used in the …

Efficacy of olmesartan, irbesartan and telmisartan against acute indomethacin-induced gastric ulcers in mice

S Khallouf, R Makhous, R Issa - Bulletin of Pharmaceutical Sciences …, 2022 - journals.ekb.eg
Recent studies have determined detrimental effects of angiotensin-II in gastric mucosa. This
study aims to investigate the gastroprotective role of some Angiotensin-II receptor blockers …

NSAIDs 肠病时肠道防御素变化对肠道炎症反应的影响

杨红静, 车筑平, 李红灵, 李林俊, 肖源, 谭庆华 - 实用医学杂志, 2014 - cqvip.com
目的: 探讨大鼠NSAIDs 肠病时肠道防御素变化对肠道炎症反应的影响. 方法: 34 只SD
大鼠随机分为模型组及对照组, 每组17 只. 免疫组化检测回肠组织r AD-5, r AD-6 的IOD 值 …