Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …

Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation.
Sterile inflammation can be caused by damage-associated molecular patterns that are …

Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five
diseases in Germany causing the highest suffering of the patients and cost for the society …

Osteoarthritis (OA) is one of the rapidly growing disability-associated conditions with
population aging worldwide. There is a pressing need for precise diagnosis and timely …

Accumulation of senescent chondrocytes is thought to drive inflammatory processes and
subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis …

Knee osteoarthritis (OA) is a degenerative knee joint disease that results from the
breakdown of joint cartilage and underlying bone, affecting about 3.3% of the world's …

Cartilage progenitor/stem cells (CPCs) are promising seed cells for cartilage regeneration,
but their fate changes and regulatory mechanisms in osteoarthritis (OA) pathogenesis …

The incidence of musculoskeletal diseases is steadily increasing with aging of the
population. In the past years, extracellular vesicles (EVs) have gained attention in …

Chondrocyte hypertrophy is one of the key indicators in the progression of osteoarthritis
(OA). However, compared with other OA indications, such as cartilage collapse, sclerosis …