Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

The oncoprotein MDM2, a major ubiquitin E3 ligase of tumor suppressor p53, has been
suggested as a novel target for human cancer therapy based on its p53-dependent and p53 …

There is currently much interest in the idea of restoring p53 activity in tumor cells by
inhibiting Hdm2/Mdm2. However, it has remained unclear whether this would also activate …

Antisense oligonucleotides can regulate gene expression in living cells. As such, they
regulate cell function and division, and can modulate cellular responses to internal and …

Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2
frequently occur in human cancers, and are associated with poor prognosis, advanced forms …

The activity and stability of the p53 tumor suppressor are regulated by the human
homologue of the mouse double minute 2 (Hdm2) oncoprotein. It has been hypothesized …

Although previous studies suggested that the tumorigenicity of mouse double minute 2
(MDM2) was due to its negative regulation of p53, the p53-independent interactions may be …

Background Gastric cancer is the leading cause of cancer related death worldwide.
Radiation alone or combined with chemotherapy plays important role in locally advanced …