Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Familial exudative vitreoretinopathy (FEVR) is a rare inherited disorder of retinal
angiogenesis. Cases can be autosomal dominant, autosomal recessive, or X-linked. FEVR …

In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

The development of the ocular vasculatures is perfectly synchronized to provide the
nutritional and oxygen requirements of the forming human eye. The fetal vasculature of …

Pericytes were described in 1873 by the French scientist Charles-Marie Benjamin Rouget
and were originally called Rouget cells. The Rouget cell was renamed some years later due …

Lack of collagen XVIII/endostatin results in eye abnormalities | The EMBO Journal Skip to
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Abstract The French scientist Charles Benjamin Rouget identified the pericyte nearly 140
years ago. Since that time the role of the pericyte in vascular function has been difficult to …

An understanding of normal and abnormal ocular development is essential to the broader
subjects of anatomy, physiology, and pathology. Embryology provides both insight into the …

Macromolecules comprise only 2% of vitreous, yet are responsible for its gel state,
transparency, and physiologic function (s) within the eye. Myopia and aging alter collagen …

The retina remains the best studied part of the human brain. Embryologically part of the
central nervous system [1–5], but readily accessible to examination, it can be investigated …