Developing strategies toward safe and effective drug delivery into the central nervous
system (CNS) with improved targeting abilities and reduced off-target effects is crucial. CNS …

Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing
neurological morbidity and mortality worldwide. In the pathophysiological process of IS …

The immune response to ischemic stroke is an area of study that is at the forefront of stroke
research and presents promising new avenues for treatment development. Upon cerebral …

Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

As resident component of the innate immunity in the central nervous system (CNS),
microglia are key players in pathology. However, they also exert fundamental roles in brain …

Microglial activation is considered as the critical pathogenic event in diverse central nervous
system disorders including cerebral ischemia. Proinflammatory responses of activated …

It is widely known that ischemic stroke is the prominent cause of death and disability. To
date, neuroinflammation following ischemic stroke represents a complex event, which is an …

Various preclinical stroke models have demonstrated the neuroprotective effects of
extracellular vesicles (EVs) obtained from several types of cells, including neurons …

Stroke remains the leading cause of long-term disability worldwide with significant long-term
sequelae. However, there is no highly effective treatment to enhance post-stroke recovery …