Sleep changes across the lifespan, with a delay in sleep timing and a reduction in slow
wave sleep seen in adolescence, followed by further reductions in slow wave sleep but a …

Circadian and homeostatic sleep-wake regulatory processes interact in a fine tuned manner
to modulate human cognitive performance. Dampening of the circadian alertness signal and …

In the last three decades the two‐process model of sleep regulation has served as a major
conceptual framework in sleep research. It has been applied widely in studies on fatigue …

Why do we go to sleep late and struggle to wake up on time? Historically, light-dark cycles
were dictated by the solar day, but now humans can extend light exposure by switching on …

A biophysical model of the key aspects of melatonin synthesis and excretion has been
developed, which is able to predict experimental dynamics of melatonin in plasma and …

Sleep is essential for the maintenance of the brain and the body, yet many features of sleep
are poorly understood and mathematical models are an important tool for probing proposed …

Jetlag is a combination of travel fatigue and circadian misalignment resulting from air travel
across time zones. Routinely recommended interventions based on circadian science …

Mathematical modeling has played a significant role in building our understanding of sleep–
wake and circadian behavior. Over the past 40 years, phenomenological models, including …

Within the human population, there is large interindividual variability in the timing of sleep
and circadian rhythms. This variability has been attributed to individual differences in sleep …

Although disturbances of the circadian system are strongly linked to affective disorders, no
known studies have examined melatonin profiles in young people in early stages of illness …