The objective of this study was to review loss of response and need for adalimumab dose
intensification in adult and pediatric patients with Crohn's disease. Studies were identified …

Women with inflammatory bowel disease (IBD) have similar rates of fertility to the general
population, but have an increased rate of adverse pregnancy outcomes compared with the …

Children and adolescents with Crohn's disease (CD) present often with a more complicated
disease course compared to adult patients. In addition, the potential impact of CD on growth …

Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and
systemic flushing accompanied by extensive sterile pustules. The committee of the …

BACKGROUND & AIMS: The IMAgINE 1 study (NCT00409682) evaluated the safety and
efficacy of adalimumab double-blind maintenance dosing regimens following open-label …

Methods To construct this review article, we performed a systematic review of the literature to
identify relevant studies comparing anti-TNF monotherapy to combination therapy with an …

IBD is a chronic immune-mediated condition of the GI tract in which the goal of treatment is
to induce and maintain durable remission. Although classically divided into Crohn disease …

Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly administered to children and
adolescents with juvenile idiopathic arthritis (JIA) and pediatric inflammatory bowel disease …

Inflammatory bowel disease (IBD), most commonly referring to Crohn's disease and
ulcerative colitis, is a chronic and disabling condition with an increasing incidence in …

Tumour necrosis factor (TNF) plays an important role in the pathogenesis of immune-
mediated inflammatory diseases (IMIDs). TNF inhibition results in down-regulation of …