Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

The diagnosis of Parkinson's disease (PD) and atypical parkinsonian syndromes is difficult
due to the lack of reliable, easily accessible biomarkers. Multiple system atrophy (MSA) is a …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized
by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …

Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …

The fundamental role that alpha-synuclein (aSyn) plays in the pathogenesis of
neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy …

Multiple system atrophy (MSA) is a rare and fatal neurodegenerative disorder characterized
by a variable combination of parkinsonism, cerebellar impairment, and autonomic …