Various organic reactions, including important synthetic reactions involving C–C, C–N, and
C–O bond formation as well as reactions of biomolecules, are accelerated when the …

The application of on‐line mass spectrometry for direct analysis of chemical and other types
of process continues to grow in importance and impact. The ability of the technique to …

We report the high throughput analysis of reaction mixture arrays using methods and data
handling routines that were originally developed for biological tissue imaging. Desorption …

Phenylhydrazone formation from isatin is used to examine the effects on the reaction rate of
(i) electrospray emitter distance from the mass spectrometer (MS) inlet,(ii) emitter tip …

Sharpless and co‐workers previously studied the [2σ+ 2σ+ 2π] cycloaddition of diethyl
azodicarboxylate (DEAD) and quadricyclane and reported that the addition of water to the …

Lomustine, an important agent for treatment of brain tumors and Hodgkin's lymphoma, has
been synthesized using continuous flow methodology. Desorption electrospray ionization …

We demonstrate the use of accelerated reactions with desorption electrospray ionization
mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfluidic reactions …

Suzuki cross-coupling is a widely performed reaction, typically using metal catalysts under
heated conditions. Acceleration of the Suzuki cross-coupling reaction has been previously …

A highly integrated approach to the development of a process for the continuous synthesis
and purification of diphenhydramine is reported. Mass spectrometry (MS) is utilized …

Since the 1990s, concerted attempts have been made to improve the efficiency of medicinal
chemistry synthesis tasks using automation. Although impacts have been seen in some …