Over the past 40 years, the muscarinic acetylcholine receptor family, particularly the M1-
receptor and M4-receptor subtypes, have emerged as validated targets for the symptomatic …

G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a
critical role in nervous system function by transmitting signals between cells and their …

Acetylcholine (ACh) in cortical neural circuits mediates how selective attention is sustained
in the presence of distractors and how flexible cognition adjusts to changing task demands …

Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by mutations in the
X chromosome-linked gene Methyl-CpG Binding Protein 2 (MECP2). Restoring MeCP2 …

Alzheimer's disease (AD) is the most prevalent type of dementia, disproportionately affecting
females, who make up nearly 60% of diagnosed cases. In AD patients, the accumulation of …

Mood disorders are highly prevalent and heterogenous mental illnesses with devastating
rates of mortality and treatment resistance. The molecular basis of those conditions involves …

Herein we report progress toward a backup clinical candidate to the M1 positive allosteric
modulator (PAM) VU319/ACP-319. Scaffold-hopping from the pyrrolo [2, 3-b] pyridine-based …

There are> 800 human G protein-coupled receptors (GPCRs). Around half (400) have
sensory functions mediating olfaction, taste, light perception, and pheromone signalling. The …

Neuroinflammation is a critical factor that contributes to neurological impairment and is
closely associated with the onset and progression of neurodegenerative diseases. In the …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases on a
global scale. Historically, this pathology has been linked to cholinergic transmission, and …