The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple
signal transduction pathways, including three groups of mitogen-activated protein (MAP) …

Human-made information relay systems invariably incorporate central regulatory
components, which are mirrored in biological systems by dense feedback and feedforward …

Flow cytometry is an essential tool for dissecting the functional complexity of hematopoiesis.
We used single-cell “mass cytometry” to examine healthy human bone marrow, measuring …

Mesenchymal stem cells (MSCs) have been exploited as cellular vectors to treat a wide
array of diseases but the mechanisms responsible for their therapeutic effect remain …

Stimulus-induced nuclear factor-κB (NF-κB) activity, the central mediator of inflammatory
responses and immune function, comprises a family of dimeric transcription factors that …

Human organoids could facilitate research of complex and currently incurable
neuropathologies, such as age-related macular degeneration (AMD) which causes …

Immunoblotting (also known as Western blotting) combined with digital image analysis can
be a reliable method for analyzing the abundance of proteins and protein modifications, but …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

Constitutive expression of the inflammatory cytokine tumor necrosis factor-α (TNF-α) is
characteristic of malignant ovarian surface epithelium. We investigated the hypothesis that …

Diabetes and obesity are worldwide health problems. White fat dynamically participates in
hormonal and inflammatory regulation. White adipose tissue is recognized as a multifactorial …