Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder
characterized by pathological deposition of misfolded self-protein amyloid beta (Aβ) which in …

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the
accumulation of amyloid plaques and neurofibrillary tangles in the brain. The AD …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

As a major arm of the cellular immune response, CD4+ T cells are important in the control
and clearance of infections. Primarily described as helpers, CD4+ T cells play an integral …

The past decade has seen the convergence of a series of new insights that arose from
genetic and systems analyses of Alzheimer's disease (AD) with a wealth of epidemiological …

Neurodegenerative diseases are a major cause of death and disability worldwide and are
influenced by many factors including age, genetics, and injuries. While these diseases are …

Regulatory T cells (Tregs) control inflammation and maintain immune homeostasis. The well-
characterised circulatory population of CD4+ Foxp3+ Tregs is effective at preventing …