Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance

Y Ren, X Mao, H Xu, Q Dang, S Weng, Y Zhang… - Cellular and Molecular …, 2023 - Springer
Iron-dependent lipid peroxidation causes ferroptosis, a form of regulated cell death. Crucial
steps in the formation of ferroptosis include the accumulation of ferrous ions (Fe2+) and lipid …

Aspects of the epigenetic regulation of EMT related to cancer metastasis

E Nowak, I Bednarek - Cells, 2021 - mdpi.com
Epithelial to mesenchymal transition (EMT) occurs during the pathological process
associated with tumor progression and is considered to influence and promote the …

Co-delivery of hesperetin and cisplatin via hyaluronic acid-modified liposome for targeted inhibition of aggression and metastasis of triple-negative breast cancer

X Wang, Y Song, L Yu, X Xue, M Pang… - … Applied Materials & …, 2023 - ACS Publications
Having no specific therapy for triple-negative breast cancer (TNBC), this subtype has the
lowest survival rate and highest metastatic risk of breast cancer since the tumor inflammatory …

Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues …

K Li, J Wu, S Xu, X Li, Y Zhang, X Gao - Microbiology Spectrum, 2023 - Am Soc Microbiol
The host–bacterial interactions play the key role in inflammatory bowel disease (IBD).
Dysbiosis of the intestinal flora can lead to pathological changes in the intestine. Rosmarinic …

The role of miRNA in renal fibrosis leading to chronic kidney disease

A Gluba-Sagr, B Franczyk, M Rysz-Górzyńska… - Biomedicines, 2023 - mdpi.com
Chronic kidney disease (CKD) is an important health concern that is expected to be the fifth
most widespread cause of death worldwide by 2040. The presence of chronic inflammation …

Epithelial mesenchymal transition (EMT) and associated invasive adhesions in solid and haematological tumours

D Greaves, Y Calle - Cells, 2022 - mdpi.com
In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

Emerging role of chemokines in small cell lung cancer: Road signs for metastasis, heterogeneity, and immune response

P Khan, M Fatima, MA Khan, SK Batra… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is a recalcitrant, relatively immune-cold, and deadly subtype
of lung cancer. SCLC has been viewed as a single or homogenous disease that includes …

3D spheroid configurations are possible indictors for evaluating the pathophysiology of melanoma cell lines

H Ohguro, M Watanabe, T Sato, F Hikage, M Furuhashi… - Cells, 2023 - mdpi.com
To study the molecular mechanisms responsible for inducing the spatial proliferation of
malignant melanomas (MM), three-dimension (3D) spheroids were produced from several …

Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study

HC Kung, J Yu - MedComm, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with a
high rate of recurrence and a dismal 5‐year survival rate. Contributing to the poor prognosis …

Extracellular vesicles: A new diagnostic biomarker and targeted drug in osteosarcoma

X Gao, B Gao, S Li - Frontiers in Immunology, 2022 - frontiersin.org
Osteosarcoma (OS) is a primary bone cancer that is highly prevalent among adolescents
and adults below the age of 20 years. The prognostic outcome of metastatic OS or relapse is …