Impact of sex hormones on immune function and multiple sclerosis development

MC Ysrraelit, J Correale - Immunology, 2019 - Wiley Online Library
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) affecting young people and leading to demyelination and neurodegeneration. The …

The maternal immune system during pregnancy and its influence on fetal development

SS Morelli, M Mandal, LT Goldsmith… - … and Reports in …, 2015 - Taylor & Francis
The maternal immune system plays a critical role in the establishment, maintenance, and
completion of a healthy pregnancy. However, the specific mechanisms utilized to achieve …

hCGs: different sources of production, different glycoforms and functions

T Fournier, J Guibourdenche, D Evain-Brion - Placenta, 2015 - Elsevier
Human chorionic gonadotropin (hCG) is the first hormonal message from the placenta to the
mother. It is detectable in maternal blood two days after implantation and behaves like an …

Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum

E Bränn, Å Edvinsson, A Rostedt Punga… - Scientific reports, 2019 - nature.com
During pregnancy, the woman's body undergoes tremendous changes in immune system
adaptation. The immunological shifts that occur in pregnancy can partially be explained by …

The challenge presented by progestins in ecotoxicological research: a critical review

V Kumar, AC Johnson, A Trubiroha… - … science & technology, 2015 - ACS Publications
Around 20 progestins (also called gestagens, progestogens, or progestagens) are used
today in assisting a range of medical conditions from endometrial cancer to uterine bleeding …

Characterizing the brain structural adaptations across the motherhood transition

M Martínez-García, M Paternina-Die… - Frontiers in Global …, 2021 - frontiersin.org
Women that become mothers face notable physiological adaptations during this life-period.
Neuroimaging studies of the last decade have provided grounded evidence that women's …

Multiple sclerosis and neuroinflammation: the overview of current and prospective therapies

I Bjelobaba, D Savic, I Lavrnja - Current pharmaceutical design, 2017 - ingentaconnect.com
Persistent neuroinflammation is now recognized as a chief pathological component of
practically all neurodegenerative diseases. Neuroinflammation in the central nervous …

Human chorionic gonadotrophin: new pleiotropic functions for an “old” hormone during pregnancy

V Gridelet, S Perrier d'Hauterive, B Polese… - Frontiers in …, 2020 - frontiersin.org
Human chorionic gonadotrophin (hCG) is the first specific molecule synthesized by the
embryo. hCG RNA is transcribed as early as the eight-cell stage, and the blastocyst …

Cytokine see‐saw across pregnancy, its related complexities and consequences

A Meyyazhagan, H Kuchi Bhotla… - … of Gynecology & …, 2023 - Wiley Online Library
During pregnancy, a woman's immune system adapts to the changing hormonal
concentrations, causing immunologic transition. These immunologic changes are required …

SeXX matters in multiple sclerosis

F Gilli, KD DiSano, AR Pachner - Frontiers in neurology, 2020 - frontiersin.org
Multiple sclerosis (MS) is the most common chronic inflammatory and neurodegenerative
disease of the central nervous system (CNS). An interesting feature that this debilitating …