The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

While the human microbiome's structure and function have been extensively studied, its
within-species genetic diversity is less well understood. However, genetic mutations in the …

Genetic and paleoanthropological evidence is in accord that today's human population is
the result of a great demic (demographic and geographic) expansion that began …

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium
tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely …

A small number of high-burden countries account for the majority of tuberculosis cases
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history …

Mycobacterium tuberculosis (M. tb), the cause of tuberculosis (TB), is estimated to infect a
new host every second. While analyses of genetic data from natural populations of M. tb …

Mycobacterium tuberculosis (M. tb) is a globally distributed, obligate pathogen of humans
that can be divided into seven clearly defined lineages. An emerging consensus places the …

The last century has witnessed progress in the study of ancient infectious disease from
purely medical descriptions of past ailments to dynamic interpretations of past population …

The consequences of the clonality of the Mycobacterium tuberculosis complex are described
and, in particular, the identification of clonal complexes. Clonal complexes are groups of …

Abstract Background. Between November 2011 and November 2012, a Canadian village of
933 persons had 50 culture-positive cases of tuberculosis, with 49 sharing the same …