Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …

Attributable to its late diagnosis, early metastasis, and poor prognosis, pancreatic cancer
remains one of the most lethal diseases worldwide. Unlike other solid tumors, pancreatic …

Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids,
flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants …

Hypoxia is an important feature of the tumor microenvironment, and is closely associated
with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these …

In order to meet the high energy demand, a metabolic reprogramming occurs in cancer cells.
Its role is crucial in promoting tumor survival. Among the substrates in demand, oxygen is …

The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …

Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …