The IGF-binding protein family contains six members that share significant structural
homology. Their principal function is to regulate the actions of IGF1 and IGF2. These …

Insulin-like growth factors (IGFs) circulate in extracellular fluids bound to a family of binding
proteins. Although they function in a classical manner to limit the access of the IGFs to their …

Importance Youth-onset type 2 diabetes (T2D) has a more aggressive phenotype than adult-
onset T2D, including rapid loss of glycemic control and increased complication risk …

A functional relationship is suggested between two well-known protein hormones, insulin-
like growth factor 1 (IGF-1) and adiponectin. In the last two decades in fact, different …

Purpose The study was designed to investigate the profile of plasma human growth
cytokines in pediatric vasovagal syncope (VVS). Materials and methods In the discovery set …

This study examines the impact of insulin-like growth factor 1 (IGF-1) and insulin-like growth
factor 2 (IGF-2) on various aspects of children's health—from the realms of growth and …

Context Observational studies have demonstrated associations between plasma proteins
and obesity, but evidence of causal relationship remains to be studied. Objective We aimed …

Left ventricular hypertrophy (LVH) is independently associated with a higher risk of
cardiovascular morbidity and mortality in adults. Adiposity is a risk factor for LVH …

Insulin-like growth factor-binding protein-1 (IGFBP-1) contributes to the regulation of IGFs for
metabolism and growth and has IGF-independent actions. IGFBP-1 in the circulation is …

Background: Obesity, diabetes, and associated diseases are increasing all over the world,
and pose a great burden on public health. According to the latest reports, 440 million people …