Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics

MR Timm, SK Russell, SJ Hultgren - Nature Reviews Microbiology, 2024 - nature.com
Urinary tract infections (UTIs), which include any infection of the urethra, bladder or kidneys,
account for an estimated 400 million infections and billions of dollars in health-care …

Dysbiosis of the human urinary microbiome and its association to diseases affecting the urinary system

S Jayalath, D Magana-Arachchi - Indian Journal of Microbiology, 2022 - Springer
The human urinary microbiome, also termed urobiome, has been overlooked due to the
clinical dogma of sterile urine, as reported by routine culture. However, evolving sensitive …

Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenic Escherichia coli

AJ Lewis, AC Richards, AA Mendez… - Infection and …, 2024 - Am Soc Microbiol
Traditional folk treatments for the prevention and management of urinary tract infections
(UTIs) and other infectious diseases often include plants and plant extracts that are rich in …

Intestinal microbiology and urinary tract infection associated risk in long-term aged care residents

SJ Miller, L Carpenter, SL Taylor… - Communications …, 2024 - nature.com
Background Urinary tract infections (UTI) are the most frequently diagnosed infection in
residents of long-term care and are a major risk factor for urosepsis, hospitalisation, and …

Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus

K Zhang, RF Potter, J Marino, CE Muenks… - Msystems, 2023 - Am Soc Microbiol
Staphylococcus saprophyticus is the leading Gram-positive cause of uncomplicated urinary
tract infections. Recent reports of increasing antimicrobial resistance (AMR) in S …

Genetic and functional enrichments associated with Enterococcus faecalis isolated from the urinary tract

BM Sharon, AP Arute, A Nguyen, S Tiwari… - Mbio, 2023 - Am Soc Microbiol
Enterococcus faecalis is the leading Gram-positive bacterial species implicated in urinary
tract infection (UTI). An opportunistic pathogen, E. faecalis is a commensal of the human …

A 21-year survey of Escherichia coli from bloodstream infections (BSI) in a tertiary hospital reveals how community-hospital dynamics of B2 phylogroup clones …

I Rodríguez, AS Figueiredo, M Sousa, S Aracil-Gisbert… - Msphere, 2021 - Am Soc Microbiol
This is a longitudinal study comprising 649 Escherichia coli isolates representing all 7,165
E. coli bloodstream infection (BSI) episodes recorded in a hospital (1996 to 2016). Strain …

Previous antibiotic exposure reshapes the population structure of infecting uropathogenic Escherichia coli strains by selecting for antibiotic resistance over …

GA Ballash, D Diaz-Campos, JC van Balen… - Microbiology …, 2023 - Am Soc Microbiol
Antibiotic therapy is the standard of care for urinary tract infections (UTIs) caused by
uropathogenic Escherichia coli (UPEC). However, previous antibiotic therapy may impart a …

Current and emerging strategies to curb antibiotic-resistant urinary tract infections

A Simoni, L Schwartz, GY Junquera, CB Ching… - Nature Reviews …, 2024 - nature.com
Rising rates of antibiotic resistance in uropathogenic bacteria compromise patient outcomes
and prolong hospital stays. Consequently, new strategies are needed to prevent and control …

Longitudinal analysis at three oral sites links oral microbiota to clinical outcomes in allogeneic hematopoietic stem-cell transplant

V Heidrich, FH Knebel, JS Bruno… - Microbiology …, 2023 - Am Soc Microbiol
Allogeneic hematopoietic stem-cell transplant (allo-HSCT) is potentially curative for several
hematological disorders. Before stem-cell infusion, recipients undergo a conditioning …