Chronic kidney disease (CKD) is a major public health concern, underscoring a need to
identify pathogenic mechanisms and potential therapeutic targets. Reactive oxygen species …

Nitric oxide (NO) is a gas that induces relaxation of smooth muscle cells in the vasculature.
Because NO reacts with oxyhaemoglobin with high affinity, the gas is rapidly scavenged by …

Importance In children undergoing heart surgery, nitric oxide administered into the gas flow
of the cardiopulmonary bypass oxygenator may reduce postoperative low cardiac output …

Acute kidney injury (AKI) is a common complication in cardiac surgery patients, with a
reported incidence of 20 to 30%. The development of AKI is associated with worse short-and …

During hemolysis, macrophages in the liver phagocytose damaged erythrocytes to prevent
the toxic effects of cell-free hemoglobin and heme. It remains unclear how this homeostatic …

Inhaled nitric oxide (iNO) acts as a selective pulmonary vasodilator and it is currently
approved by the FDA for the treatment of persistent pulmonary hypertension of the newborn …

Objective Acute kidney injury (AKI) is a serious complication of cardiac surgery with
cardiopulmonary bypass (CPB). The aim of this study was to evaluate the effects of nitric …

Pulmonary hypertension (PH) is a severe disease that affects people of all ages. It can occur
as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary …

Abstract Background and Aims Contrast-induced nephropathy (CIN), also known as contrast-
associated acute kidney injury (CA-AKI) underlies a significant proportion of the morbidity …

Perioperative organ injury remains a medical, social and economic problem in cardiac
surgery. Patients with postoperative organ dysfunction have increases in morbidity, length of …