Utility of B-factors in protein science: interpreting rigidity, flexibility, and internal motion and engineering thermostability
Z Sun, Q Liu, G Qu, Y Feng, MT Reetz - Chemical reviews, 2019 - ACS Publications
The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …
displacement parameter, is used in protein crystallography to describe the attenuation of X …
Review of ligand specificity factors for CYP1A subfamily enzymes from molecular modeling studies reported to-date
J Sridhar, N Goyal, J Liu, M Foroozesh - Molecules, 2017 - mdpi.com
The cytochrome P450 (CYP) family 1A enzymes, CYP1A1 and CYP1A2, are two of the most
important enzymes implicated in the metabolism of endogenous and exogenous …
important enzymes implicated in the metabolism of endogenous and exogenous …
Hydration and Structural Adaptations of the Human CYP1A1, CYP1A2, and CYP1B1 Active Sites by Molecular Dynamics Simulations
Z Dutkiewicz, R Mikstacka - International Journal of Molecular Sciences, 2023 - mdpi.com
Cytochromes CYP1A1, CYP1A2, and CYP1B1, the members of the cytochrome P450 family
1, catalyze the metabolism of endogenous compounds, drugs, and non-drug xenobiotics …
1, catalyze the metabolism of endogenous compounds, drugs, and non-drug xenobiotics …
Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach
AC Hachey, AD Fenton, DK Heidary… - Journal of Medicinal …, 2022 - ACS Publications
Cytochrome P450 1B1 (CYP1B1) is a potential drug target in cancer research that is
overexpressed in several solid tumors but is present only at low levels in healthy tissues. Its …
overexpressed in several solid tumors but is present only at low levels in healthy tissues. Its …
Inhibition of human and rat CYP1A1 enzyme by grapefruit juice compounds
R Santes-Palacios, A Romo-Mancillas… - Toxicology Letters, 2016 - Elsevier
Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic
hydrocarbons; therefore, its inhibition interferes with the carcinogenesis process induced by …
hydrocarbons; therefore, its inhibition interferes with the carcinogenesis process induced by …
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1
JP Connick, JR Reed, GF Cawley… - Biochemical …, 2021 - portlandpress.com
P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with
the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when …
the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when …
Characterization of differences in substrate specificity among CYP1A1, CYP1A2 and CYP1B1: an integrated approach employing molecular docking and molecular …
SS Kesharwani, PP Nandekar… - Journal of Molecular …, 2016 - Wiley Online Library
Recent trends in new drug discovery of anticancer drugs have made oncologists more
aware of the fact that the new drug discovery must target the developing mechanism of …
aware of the fact that the new drug discovery must target the developing mechanism of …
Identification of leads for antiproliferative activity on MDA-MB-435 human breast cancer cells through pharmacophore and CYP1A1-mediated metabolism
CYP1A1 is a potential target for anticancer drug development due to its overexpression in
certain cancer cells and role in cancer progression. To identify new leads for CYP1A1 …
certain cancer cells and role in cancer progression. To identify new leads for CYP1A1 …
大鼠减体积肝移植术后移植肝脏应激蛋白的差异表达研究.
刘静， 李立， 冉江华， 张升宁， 李来邦… - … /Qi Guan Yi Zhi, 2015 - search.ebscohost.com
目的探讨大鼠减体积肝移植术后肝脏应激蛋白的差异表达情况. 方法分别将改良大鼠减体积肝
移植模型术后1, 3, 7d 的肝脏组织标本的双向电泳图谱与供体和受体原肝脏组织的双向电泳图谱 …
移植模型术后1, 3, 7d 的肝脏组织标本的双向电泳图谱与供体和受体原肝脏组织的双向电泳图谱 …
Functional characterization of CYP1A9 and CYP1C1 from Anguillus japonica
T Uno, C Izumi, S Takenaka, T Yanase… - Environmental …, 2015 - Elsevier
We evaluated the metabolism of several herbicides and progesterone by two P450 proteins
(CYP1A9 and CYP1C1) from Japanese eel (Anguilla japonica). Expression vectors …
(CYP1A9 and CYP1C1) from Japanese eel (Anguilla japonica). Expression vectors …