INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …

APE1 (DNA (apurinic/apyrimidinic site) endonuclease 1) is a key enzyme of one of the major
DNA repair routes, the BER (base excision repair) pathway. APE1 fulfils additional functions …

Electron microscopy‐based DNA imaging is a powerful tool that provides a high resolution
for observing genomic structures involved in biochemical processes. The first method, heavy …

Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to
aberrant end-joining reactions leading to chromosomal fusions and translocations. Human …

Human apurinic/apyrimidinic endonuclease 1 (APE1) is known to be a critical player of the
base excision repair (BER) pathway. In general, BER involves consecutive actions of DNA …

The primary role of apurinic/apyrimidinic (AP) endonuclease APE1 in human cells is the
cleavage of the sugar phosphate backbone 5′ to an AP site in DNA to produce a single …

Base excision repair (BER) maintains genomic stability through the repair of DNA damage.
Within BER, AP-endonuclease 1 (APE1) is a multifunctional enzyme that processes DNA …

Coordination of enzymatic activities in the course of base excision repair (BER) is essential
to ensure complete repair of damaged bases. Two major mechanisms underlying the …

Background Hepatocellular carcinoma (HCC) is the leading cause of primary liver cancers.
Surveillance of individuals at specific risk of developing HCC, early diagnostic markers, and …

Aerobic respiration generates reactive oxygen species (ROS), which can damage nucleic
acids, proteins and lipids. A number of transcription factors (TFs) contain redox-sensitive …