Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …

In violation of the'one gene, one polypeptide'rule, alternative splicing allows individual
genes to produce multiple protein isoforms—thereby playing a central part in generating …

Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …

Single-cell RNA-seq mammalian transcriptome studies are at an early stage in uncovering
cell-to-cell variation in gene expression, transcript processing and editing, and regulatory …

Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Introduction Blood production in humans culminates in the daily release of around 1011
cells into the circulation, mainly platelets and red blood cells. All blood cells originate from a …

Background Recently, genomic sequencing efforts were finished for Oryza sativa (cultivated
rice) and Arabidopsis thaliana (Arabidopsis). Additionally, these two plant species have …

Understanding the molecular mechanisms responsible for the regulation of the
transcriptome present in eukaryotic cells is one of the most challenging tasks in the …

Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and
psoriasis are triggered by hitherto unknown environmental factors that function on the …

The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic
syndromes (MDS), and is strongly associated with the presence of ring sideroblasts (RS) …